Page last updated: 2024-11-09

2-[[benzamido(sulfanylidene)methyl]amino]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid

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Description

CID1067700: a pan-GTPase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1067700
CHEMBL ID1328505
CHEBI ID122039
SCHEMBL ID15647854

Synonyms (52)

Synonym
CBMICRO_017018 ,
cid-1067700
314042-01-8
KUC103669N ,
HMS2593N14
2-{[(benzoylamino)carbonothioyl]amino}-5,5-dimethyl-4,7-dihydro-5h-thieno[2,3-c]pyran-3-carboxylic acid
smr000297947
MLS000673908 ,
CHEMDIV1_021248
BIM-0017116.P001
ml282
UNM-0000305820
5,5-dimethyl-2-{[(phenylcarbonyl)carbamothioyl]amino}-4,7-dihydro-5h-thieno[2,3-c]pyran-3-carboxylic acid
STK026535
CHEBI:122039
cid1067700
HMS647F18
2-(benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid
AKOS001627836
ksc-228-080-1
KUC103669N-02
MLS003884829
CCG-13339
KUC103669N-04
ksc-308-57-1
KUC103669N-03
ksc-4-143-resupply
NCGC00347068-01
2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4h-thieno[2,3-c]pyran-3-carboxylic acid
AB00100899-01
HMS3380I15
CHEMBL1328505
cid_1067700
2-(benzoylthiocarbamoylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid
bdbm43221
2-[[benzamido(sulfanylidene)methyl]amino]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid
5,5-dimethyl-2-(phenylcarbonylcarbamothioylamino)-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid
MLS006011907
SCHEMBL15647854
cid 1067700
Q27210667
DTXSID80360013
SR-01000431437-1
sr-01000431437
BCP06876
AS-16524
HY-13452
CS-0006906
mfcd01557530
D83420
cid-1067700,2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4h-thieno[2,3-c]pyran-3-carboxylic acid
2-(3-benzoylthioureido)-5,5-dimethyl-4,7-dihydro-5h-thieno[2,3-c]pyran-3-carboxylic acid

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
thienopyran
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (27)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency89.12510.044717.8581100.0000AID485294
LuciferasePhotinus pyralis (common eastern firefly)Potency21.33130.007215.758889.3584AID588342
Microtubule-associated protein tauHomo sapiens (human)Potency10.00000.180013.557439.8107AID1460
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency5.62340.707912.194339.8107AID720542
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency22.38720.011212.4002100.0000AID1030
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency9.52210.01237.983543.2770AID1645841
EWS/FLI fusion proteinHomo sapiens (human)Potency29.69660.001310.157742.8575AID1259252; AID1259253; AID1259256
GVesicular stomatitis virusPotency18.99910.01238.964839.8107AID1645842
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.11870.707936.904389.1251AID504333
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency39.81070.035520.977089.1251AID504332
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency31.62280.036619.637650.1187AID2100
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
Interferon betaHomo sapiens (human)Potency18.99910.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency18.99910.01238.964839.8107AID1645842
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency18.99910.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency18.99910.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
phospholipase A2 precursorHomo sapiens (human)IC50 (µMol)13.10001.02009.002515.2000AID588400
cysteine protease ATG4B isoform aHomo sapiens (human)IC50 (µMol)21.10001.250010.663219.1000AID504756
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GTP-binding protein (rab7)Canis lupus familiaris (dog)EC50 (µMol)0.17140.02201.21466.4190AID1336; AID588393; AID588394; AID588631
ras protein, partialHomo sapiens (human)EC50 (µMol)0.08490.02000.22371.9660AID1335; AID1341; AID588381; AID588383; AID588387; AID588388; AID588628; AID588630
Rac1 proteinHomo sapiens (human)EC50 (µMol)0.08060.02025.986029.5100AID1340
cell division cycle 42 (GTP binding protein, 25kDa), partialHomo sapiens (human)EC50 (µMol)0.08680.05633.055413.5100AID1333; AID1334; AID588373; AID588384; AID588385
cell division control protein 42 homolog isoform 1 precursorHomo sapiens (human)EC50 (µMol)0.12900.12901.62973.9370AID588377
Ras-related protein Rab-7aHomo sapiens (human)EC50 (µMol)0.03070.02200.03070.0400AID1425597; AID1425599; AID1425622; AID1425624; AID1425626; AID1425638
Cell division control protein 42 homologHomo sapiens (human)EC50 (µMol)0.02000.02000.02000.0200AID1425627; AID1425628
Ras-related protein Rab-2AHomo sapiens (human)EC50 (µMol)0.02000.02000.02000.0200AID1425630
Ras-related protein Rab-2ACanis lupus familiaris (dog)EC50 (µMol)0.17090.15800.37770.7042AID1337
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (131)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
autophagosome assemblyRas-related protein Rab-7aHomo sapiens (human)
protein targeting to lysosomeRas-related protein Rab-7aHomo sapiens (human)
endocytosisRas-related protein Rab-7aHomo sapiens (human)
epidermal growth factor catabolic processRas-related protein Rab-7aHomo sapiens (human)
endosome to lysosome transportRas-related protein Rab-7aHomo sapiens (human)
response to bacteriumRas-related protein Rab-7aHomo sapiens (human)
protein transportRas-related protein Rab-7aHomo sapiens (human)
lipid catabolic processRas-related protein Rab-7aHomo sapiens (human)
viral release from host cellRas-related protein Rab-7aHomo sapiens (human)
protein to membrane dockingRas-related protein Rab-7aHomo sapiens (human)
retrograde transport, endosome to GolgiRas-related protein Rab-7aHomo sapiens (human)
early endosome to late endosome transportRas-related protein Rab-7aHomo sapiens (human)
bone resorptionRas-related protein Rab-7aHomo sapiens (human)
positive regulation of protein catabolic processRas-related protein Rab-7aHomo sapiens (human)
intracellular transportRas-related protein Rab-7aHomo sapiens (human)
positive regulation of viral processRas-related protein Rab-7aHomo sapiens (human)
establishment of vesicle localizationRas-related protein Rab-7aHomo sapiens (human)
lipophagyRas-related protein Rab-7aHomo sapiens (human)
phagosome maturationRas-related protein Rab-7aHomo sapiens (human)
phagosome acidificationRas-related protein Rab-7aHomo sapiens (human)
phagosome-lysosome fusionRas-related protein Rab-7aHomo sapiens (human)
endosome to plasma membrane protein transportRas-related protein Rab-7aHomo sapiens (human)
negative regulation of exosomal secretionRas-related protein Rab-7aHomo sapiens (human)
positive regulation of exosomal secretionRas-related protein Rab-7aHomo sapiens (human)
negative regulation of intralumenal vesicle formationRas-related protein Rab-7aHomo sapiens (human)
sprouting angiogenesisCell division control protein 42 homologHomo sapiens (human)
cardiac conduction system developmentCell division control protein 42 homologHomo sapiens (human)
cardiac neural crest cell migration involved in outflow tract morphogenesisCell division control protein 42 homologHomo sapiens (human)
phagocytosis, engulfmentCell division control protein 42 homologHomo sapiens (human)
actin filament organizationCell division control protein 42 homologHomo sapiens (human)
Golgi organizationCell division control protein 42 homologHomo sapiens (human)
regulation of mitotic nuclear divisionCell division control protein 42 homologHomo sapiens (human)
nuclear migrationCell division control protein 42 homologHomo sapiens (human)
establishment or maintenance of cell polarityCell division control protein 42 homologHomo sapiens (human)
integrin-mediated signaling pathwayCell division control protein 42 homologHomo sapiens (human)
protein localizationCell division control protein 42 homologHomo sapiens (human)
regulation of lamellipodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of lamellipodium assemblyCell division control protein 42 homologHomo sapiens (human)
substantia nigra developmentCell division control protein 42 homologHomo sapiens (human)
actin cytoskeleton organizationCell division control protein 42 homologHomo sapiens (human)
macrophage differentiationCell division control protein 42 homologHomo sapiens (human)
positive regulation of cell growthCell division control protein 42 homologHomo sapiens (human)
positive regulation of cell migrationCell division control protein 42 homologHomo sapiens (human)
positive regulation of pseudopodium assemblyCell division control protein 42 homologHomo sapiens (human)
negative regulation of protein-containing complex assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of cytokinesisCell division control protein 42 homologHomo sapiens (human)
regulation of actin cytoskeleton organizationCell division control protein 42 homologHomo sapiens (human)
cell junction assemblyCell division control protein 42 homologHomo sapiens (human)
adherens junction organizationCell division control protein 42 homologHomo sapiens (human)
embryonic heart tube developmentCell division control protein 42 homologHomo sapiens (human)
dendritic cell migrationCell division control protein 42 homologHomo sapiens (human)
neuropilin signaling pathwayCell division control protein 42 homologHomo sapiens (human)
positive regulation of neuron apoptotic processCell division control protein 42 homologHomo sapiens (human)
modulation by host of viral processCell division control protein 42 homologHomo sapiens (human)
establishment of epithelial cell apical/basal polarityCell division control protein 42 homologHomo sapiens (human)
positive regulation of DNA replicationCell division control protein 42 homologHomo sapiens (human)
positive regulation of JNK cascadeCell division control protein 42 homologHomo sapiens (human)
filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of pinocytosisCell division control protein 42 homologHomo sapiens (human)
neuron fate determinationCell division control protein 42 homologHomo sapiens (human)
regulation of filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of filopodium assemblyCell division control protein 42 homologHomo sapiens (human)
regulation of stress fiber assemblyCell division control protein 42 homologHomo sapiens (human)
positive regulation of stress fiber assemblyCell division control protein 42 homologHomo sapiens (human)
establishment of Golgi localizationCell division control protein 42 homologHomo sapiens (human)
positive regulation of synapse structural plasticityCell division control protein 42 homologHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionCell division control protein 42 homologHomo sapiens (human)
regulation of attachment of spindle microtubules to kinetochoreCell division control protein 42 homologHomo sapiens (human)
heart contractionCell division control protein 42 homologHomo sapiens (human)
Wnt signaling pathway, planar cell polarity pathwayCell division control protein 42 homologHomo sapiens (human)
positive regulation of epithelial cell proliferation involved in lung morphogenesisCell division control protein 42 homologHomo sapiens (human)
submandibular salivary gland formationCell division control protein 42 homologHomo sapiens (human)
dendritic spine morphogenesisCell division control protein 42 homologHomo sapiens (human)
cellular response to type II interferonCell division control protein 42 homologHomo sapiens (human)
organelle transport along microtubuleCell division control protein 42 homologHomo sapiens (human)
endothelin receptor signaling pathway involved in heart processCell division control protein 42 homologHomo sapiens (human)
actin filament branchingCell division control protein 42 homologHomo sapiens (human)
positive regulation of intracellular protein transportCell division control protein 42 homologHomo sapiens (human)
regulation of modification of postsynaptic structureCell division control protein 42 homologHomo sapiens (human)
regulation of postsynapse organizationCell division control protein 42 homologHomo sapiens (human)
modification of synaptic structureCell division control protein 42 homologHomo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingCell division control protein 42 homologHomo sapiens (human)
endocytosisCell division control protein 42 homologHomo sapiens (human)
Cdc42 protein signal transductionCell division control protein 42 homologHomo sapiens (human)
endoplasmic reticulum to Golgi vesicle-mediated transportRas-related protein Rab-2AHomo sapiens (human)
Golgi organizationRas-related protein Rab-2AHomo sapiens (human)
protein transportRas-related protein Rab-2AHomo sapiens (human)
macroautophagyRas-related protein Rab-2AHomo sapiens (human)
vesicle-mediated transportRas-related protein Rab-2AHomo sapiens (human)
Golgi organizationRas-related protein Rab-2ACanis lupus familiaris (dog)
protein transportRas-related protein Rab-2ACanis lupus familiaris (dog)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (32)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
GTPase activityRas-related protein Rab-7aHomo sapiens (human)
G protein activityRas-related protein Rab-7aHomo sapiens (human)
protein bindingRas-related protein Rab-7aHomo sapiens (human)
GTP bindingRas-related protein Rab-7aHomo sapiens (human)
GDP bindingRas-related protein Rab-7aHomo sapiens (human)
small GTPase bindingRas-related protein Rab-7aHomo sapiens (human)
retromer complex bindingRas-related protein Rab-7aHomo sapiens (human)
GTPase activityCell division control protein 42 homologHomo sapiens (human)
G protein activityCell division control protein 42 homologHomo sapiens (human)
protein bindingCell division control protein 42 homologHomo sapiens (human)
GTP bindingCell division control protein 42 homologHomo sapiens (human)
protein kinase bindingCell division control protein 42 homologHomo sapiens (human)
GTP-dependent protein bindingCell division control protein 42 homologHomo sapiens (human)
mitogen-activated protein kinase kinase kinase bindingCell division control protein 42 homologHomo sapiens (human)
thioesterase bindingCell division control protein 42 homologHomo sapiens (human)
GBD domain bindingCell division control protein 42 homologHomo sapiens (human)
apolipoprotein A-I receptor bindingCell division control protein 42 homologHomo sapiens (human)
identical protein bindingCell division control protein 42 homologHomo sapiens (human)
ubiquitin protein ligase activityCell division control protein 42 homologHomo sapiens (human)
GTPase activityRas-related protein Rab-2AHomo sapiens (human)
protein bindingRas-related protein Rab-2AHomo sapiens (human)
GTP bindingRas-related protein Rab-2AHomo sapiens (human)
GDP bindingRas-related protein Rab-2AHomo sapiens (human)
GTPase activityRas-related protein Rab-2ACanis lupus familiaris (dog)
GTP bindingRas-related protein Rab-2ACanis lupus familiaris (dog)
GDP bindingRas-related protein Rab-2ACanis lupus familiaris (dog)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (60)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lysosomeRas-related protein Rab-7aHomo sapiens (human)
late endosomeRas-related protein Rab-7aHomo sapiens (human)
retromer complexRas-related protein Rab-7aHomo sapiens (human)
autophagosome membraneRas-related protein Rab-7aHomo sapiens (human)
mitochondrionRas-related protein Rab-7aHomo sapiens (human)
lysosomeRas-related protein Rab-7aHomo sapiens (human)
lysosomal membraneRas-related protein Rab-7aHomo sapiens (human)
late endosomeRas-related protein Rab-7aHomo sapiens (human)
Golgi apparatusRas-related protein Rab-7aHomo sapiens (human)
lipid dropletRas-related protein Rab-7aHomo sapiens (human)
cytosolRas-related protein Rab-7aHomo sapiens (human)
plasma membraneRas-related protein Rab-7aHomo sapiens (human)
endosome membraneRas-related protein Rab-7aHomo sapiens (human)
secretory granule membraneRas-related protein Rab-7aHomo sapiens (human)
phagocytic vesicle membraneRas-related protein Rab-7aHomo sapiens (human)
synaptic vesicle membraneRas-related protein Rab-7aHomo sapiens (human)
late endosome membraneRas-related protein Rab-7aHomo sapiens (human)
mitochondrial membraneRas-related protein Rab-7aHomo sapiens (human)
melanosome membraneRas-related protein Rab-7aHomo sapiens (human)
phagophore assembly site membraneRas-related protein Rab-7aHomo sapiens (human)
phagocytic vesicleRas-related protein Rab-7aHomo sapiens (human)
extracellular exosomeRas-related protein Rab-7aHomo sapiens (human)
alveolar lamellar bodyRas-related protein Rab-7aHomo sapiens (human)
late endosomeRas-related protein Rab-7aHomo sapiens (human)
phagocytic vesicleRas-related protein Rab-7aHomo sapiens (human)
lysosomeRas-related protein Rab-7aHomo sapiens (human)
centrosomeCell division control protein 42 homologHomo sapiens (human)
Golgi membraneCell division control protein 42 homologHomo sapiens (human)
storage vacuoleCell division control protein 42 homologHomo sapiens (human)
cytoplasmCell division control protein 42 homologHomo sapiens (human)
endoplasmic reticulum membraneCell division control protein 42 homologHomo sapiens (human)
cytosolCell division control protein 42 homologHomo sapiens (human)
plasma membraneCell division control protein 42 homologHomo sapiens (human)
cell-cell junctionCell division control protein 42 homologHomo sapiens (human)
focal adhesionCell division control protein 42 homologHomo sapiens (human)
membraneCell division control protein 42 homologHomo sapiens (human)
secretory granuleCell division control protein 42 homologHomo sapiens (human)
filopodiumCell division control protein 42 homologHomo sapiens (human)
midbodyCell division control protein 42 homologHomo sapiens (human)
leading edge membraneCell division control protein 42 homologHomo sapiens (human)
cytoplasmic ribonucleoprotein granuleCell division control protein 42 homologHomo sapiens (human)
neuron projectionCell division control protein 42 homologHomo sapiens (human)
neuronal cell bodyCell division control protein 42 homologHomo sapiens (human)
dendritic spineCell division control protein 42 homologHomo sapiens (human)
apical part of cellCell division control protein 42 homologHomo sapiens (human)
phagocytic vesicleCell division control protein 42 homologHomo sapiens (human)
spindle midzoneCell division control protein 42 homologHomo sapiens (human)
extracellular exosomeCell division control protein 42 homologHomo sapiens (human)
mitotic spindleCell division control protein 42 homologHomo sapiens (human)
Schaffer collateral - CA1 synapseCell division control protein 42 homologHomo sapiens (human)
glutamatergic synapseCell division control protein 42 homologHomo sapiens (human)
Golgi transport complexCell division control protein 42 homologHomo sapiens (human)
protein-containing complexCell division control protein 42 homologHomo sapiens (human)
dendritic spineCell division control protein 42 homologHomo sapiens (human)
plasma membraneCell division control protein 42 homologHomo sapiens (human)
Golgi membraneRas-related protein Rab-2AHomo sapiens (human)
autophagosome membraneRas-related protein Rab-2AHomo sapiens (human)
acrosomal vesicleRas-related protein Rab-2AHomo sapiens (human)
nucleusRas-related protein Rab-2AHomo sapiens (human)
lysosomal membraneRas-related protein Rab-2AHomo sapiens (human)
endoplasmic reticulum membraneRas-related protein Rab-2AHomo sapiens (human)
cytosolRas-related protein Rab-2AHomo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membraneRas-related protein Rab-2AHomo sapiens (human)
melanosomeRas-related protein Rab-2AHomo sapiens (human)
extracellular exosomeRas-related protein Rab-2AHomo sapiens (human)
Golgi apparatusRas-related protein Rab-2AHomo sapiens (human)
Golgi membraneRas-related protein Rab-2AHomo sapiens (human)
autophagosome membraneRas-related protein Rab-2ACanis lupus familiaris (dog)
acrosomal vesicleRas-related protein Rab-2ACanis lupus familiaris (dog)
endoplasmic reticulum membraneRas-related protein Rab-2ACanis lupus familiaris (dog)
endoplasmic reticulum-Golgi intermediate compartment membraneRas-related protein Rab-2ACanis lupus familiaris (dog)
melanosomeRas-related protein Rab-2ACanis lupus familiaris (dog)
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's9 (52.94)24.3611
2020's7 (41.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.01 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.90 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]